医科大学新生善花（韩智敏）、启范（吴泰景）、忠石（温朱万）、京敏、志英和银珠被分到同一小组上解剖课，在解剖教室，面对来历不明的女尸，众人表现大相径庭，尤以优等生银珠和“万人迷”忠石反应最为突出，前者紧张尖叫转身离开，后者饶有兴致地拿起手机拍下尸体身上的老土纹身。 银珠为战胜自己，深夜只身潜进解剖教室，被杀，当众人把怀疑的目光落在将银珠当情敌的志英身上时，志英不久也死于解剖教室，因为亲见志英的挣扎，京敏疯掉。意识到一切皆被神秘力量操纵后，善花、启范和忠石为自救，开始联手欲揭开噩梦真相。
灵异纪实节目组的办公室突遭一名持刀女子闯入，造成工作人员受伤。女子深陷疯狂阴谋论，坚称必须将一盘录像带归回原处，否则全人类将会覆灭。调查团队顺着网络线索，找到了散布这套诡异说法的始作俑者。那盘神秘录像，早年曾发布在猎奇网站「死画像」，传言恐怖等级远超知名的 “邦子” 灵异片段。摄制组成功发掘出这份尘封影像，决意揭开画面背后存在物的真相，却就此踏入无法回头的险境。
Since the death of their father and mother, Ambar and Dika move to a nursing home owned by their parents' best friend and their son, Agus. There are three people in the nursing home of Masa Toea: Grandma Ani, Grandpa Farid, and Oma Ida. The three are taken care of by Rina, a nurse who is also Agus's girlfriend. Not long after Ambar and Dika's move, Oma Ida's grandson, Arthur, comes to celebrate Eid. Ambar, who has the ability to see mystical things, accidentally gets a vision from the past: Ivanna, a Dutch woman, was tortured by Japanese soldiers which resulted in losing her head. A series of mystical events begin to haunt Ambar and all the residents of the nursing home, especially after they find a headless statue in the basement along with a vinyl record containing a scary song. On the day of Eid, things got even more tense when the residents of the orphanage found that Granny Ani has died without a head. Everyone panicky, especially when one by one the mystery of Ivanna's revenge is revealed. With the safety of all the residents of the orphanage now in danger, Ambar is required to finish Ivanna's revenge, before the spirit takes their lives.
故事聚焦奉命奔赴浣熊市的医疗速递员布莱恩（奥斯汀·艾布拉姆斯 饰），意外深陷全城失控的病毒浩劫。浣熊市彻底沦陷，异变怪物横行肆虐、嗜血猎捕，身陷末日绝境的他，能否在这场惊魂噩梦中突围求生，搏出一线生机？
