故事讲述两个在当代具有超自然能力的人“乔治”和“米歇尔”。在当地一个不知名的医院里做苦工，他们生活绝望-因为米歇尔是吸血鬼，乔治是狼人。他们决定改过自新，住在了一起才发现，一个女鬼(Annie)死于神秘的情况并且经常闹鬼。在这个一个对两个人的竞赛中(Threesome 有三人一组或者一人对抗两人的意思，这里应该指安妮女鬼和乔治米歇尔搭档)，他们与超自然生物对抗，希望通过这样的生活方式与他们的邻居-人类相处。
Contemporary Supernatural Drama About George And Mitchell, A Pair Of Perennial Outsiders. Working In The Anonymous Drudgery Of The Local Hospital, They Live Lives Of Quiet Desperation - Because Mitchell Is A Vampire And George Is A Werewolf. Deciding To Turn Over A New Leaf, They Move Into A House Together, Only To Find That It Is Haunted By Annie, The Ghost Of A Woman Killed In Mysterious Circumstances. As A Threesome, They Deal With The Challenges Of Being Supernatural Creatures, Bonded By Their Desire To Adopt The Lifestyle Of Their Neighbours - Humanity.
